April 01, 2011
What is the chance of hemophilia in their children?
Category: Haemophilia
Hemophilia is a sex-linked disease. A man has a father who had hemophilia. The man has normal clotting time. He marries a woman with no record of hemophilia in her heritage. What is the chance of hemophilia in their children?
6 Responses to “What is the chance of hemophilia in their children?”
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April 1st, 2011 at 5:10 pm
I’d say about 35/50 percent chance.
April 1st, 2011 at 5:10 pm
If only the father’s father has it, it should only be a 25% chance. That vary’s during pregnancy though..
April 1st, 2011 at 5:22 pm
All his daughters have a 50% chance of getting it, since it isnt on the y chromosome. The boys will get his y, while the girls get his x…
April 1st, 2011 at 5:56 pm
well hemophilia is carried on the x chromosome and it shows only in males since they cant replace it with another x chromosome like females can. so his father is X’Y (apostrophe means bad trait). so since he is male he got an x from his mother and a healthy y from his father (which proves true because he has normal clotting time). so thus, we are saying a normal man is having children with a normal women, so thus, its a zero percent chance.
April 1st, 2011 at 6:29 pm
Zero. If the male has a normal clotting time, he doesn’t have the hemophilia allele at all (it doesn’t matter if the dad had hemophilia…he inherited the dad’s Y chromosome…hemophilia is X-linked). If he marries a woman with no record, she’s probably homozygous normal. None of the parents have the hemophilia allele, so none of the children will have it.
April 1st, 2011 at 7:10 pm
The son of the father will not have Hemophilia. He will also not have children with it. Nor will his daughters be carriers. The gene is only active in females to pass it on and it is 50-50. A father can not have a son with hemophilia but the fathers daughters will all be carriers.